General Information:
\n Like all salicylates, acetylsalicylic acid belongs to the group of non-steroidal analgesic \/ antipyretic drugs.
\n As an ester of salicylic acid, acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effect.
\nThe mechanism of action described includes inhibition of cyclooxygenase and consequent inhibition of prostaglandins:
\n prostaglandin E2, prostaglandin I2, and thromboxane A2.
\nAcetylsalicylic acid plays a strong inhibitory effect on platelet aggregation.
\n Irreversible inhibition of cyclooxygenase is more intense in platelets, due to the fact that platelets cannot remodel enzymes.
\n Acetylsalicylic acid is considered to have other inhibitory effects on platelets.
\nBased on experimental data, ibuprofen in low doses may inhibit the action of aspirin on platelet aggregation when administered concomitantly.
\n In one study, with the administration of a single dose of ibuprofen 400 mg, 8 hours before or 30 minutes after rapid release of aspirin 81 mg, a reduced activity of acetylsalicylic acid in thromboxane formation or platelet aggregation was reported .
\nIndications:
\n\u2022 For mild to moderate pain, such as headache, neuralgia, myalgia, arthralgia.
\n \u2022 Generally, in a state of fever.
\n\u2022 In various inflammatory diseases, such as rheumatic fever, active rheumatoid arthritis (juveniles and adults), osteoarthritis.
\nIn cases where the dose does not exceed 325 mg \/ day is indicated in:
\n\u2022 Prophylaxis from recurrence of myocardial infarction.
\n\u2022 To reduce the risks resulting from recurrence of ischemic stroke in men.
\n (In women the reduction of these risks has not been confirmed).
\n\u2022 Prophylaxis after transient ischemic stroke.
\n\u2022 Chronic unstable angina.
\nProphylaxis of coronary thrombotic attacks in high-risk patients, such as hypertension (after adjusting blood pressure), diabetes mellitus and hyperlipidemia, and smoking.
\n\u2022 Prophylaxis of thrombosis (prevention of re-coagulation) after aortic-coronary inoculation (BY \/ PASS) and artificial arteriovenous in patients undergoing hemodialysis.
\n\u2022 Prevention of thrombosis after percutaneous transluminal coronary angioplasty (PTCA).
\nContraindications:
\n\u2022 Hypersensitivity known to salicylates or other substances (exipients).
\n\u2022 History of asthma caused by administration of salicylates or active ingredients with similar action.
\n\u2022 Active gastro-duodenal ulcer.
\nd.
\n\u2022Severe hepatic or renal insufficiency.
\n\u2022 Severe heart problems.
\n\u2022 Bleeding disorders (eg hemophilia).
\n\u2022 Patients under heparin therapy.
\n\u2022 Patients with hypersensitivity to other AIJS drugs (such as indomethacin, phenylbutazone, ibuprofen, diflunisal).
\n\u2022 Cross-sensitivity does not exist between acetylsalicylic acid (ASA) and sodium salicylate, salicylamide or salicylic choline.
\nThis is an OTC drug, so it can be taken without a doctor’s recommendation.
\nBefore using this medicine read carefully the package leaflet as it contains more detailed information.
\nFor any uncertainty consult your doctor or pharmacist.<\/p>\n","protected":false},"excerpt":{"rendered":"
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